Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain

GC Ferreira, MC McKenna - Neurochemical research, 2017 - Springer
Abstract l-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for
degradation by β-oxidation. Treatment with l-carnitine can ameliorate metabolic imbalances …

Specialized metabolites from the microbiome in health and disease

G Sharon, N Garg, J Debelius, R Knight, PC Dorrestein… - Cell metabolism, 2014 - cell.com
The microbiota, and the genes that comprise its microbiome, play key roles in human health.
Host-microbe interactions affect immunity, metabolism, development, and behavior, and …

Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China

M Zhang, W Ma, J Zhang, Y He, J Wang - Scientific reports, 2018 - nature.com
Autism spectrum disorder (ASD) is a set of complex neurodevelopmental disorders. Recent
studies reported that children with ASD have altered gut microbiota profiles compared with …

Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

Z Liu, X Li, JT Zhang, YJ Cai, TL Cheng, C Cheng… - Nature, 2016 - nature.com
Abstract Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional
regulation and microRNA processing,,,. Mutations in the MECP2 gene are found in 90% of …

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

DR Rose, H Yang, G Serena, C Sturgeon, B Ma… - Brain, behavior, and …, 2018 - Elsevier
Objectives Many studies have reported the increased presence of gastrointestinal (GI)
symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles …

Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat

MSA Palmnäs, TE Cowan, MR Bomhof, J Su… - PloS one, 2014 - journals.plos.org
Aspartame consumption is implicated in the development of obesity and metabolic disease
despite the intention of limiting caloric intake. The mechanisms responsible for this …

Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder

S Rose, DM Niyazov, DA Rossignol… - Molecular diagnosis & …, 2018 - Springer
Autism spectrum disorder (ASD) affects~ 2% of children in the United States. The etiology of
ASD likely involves environmental factors triggering physiological abnormalities in …

[HTML][HTML] Emerging biomarkers in autism spectrum disorder: a systematic review

RE Frye, S Vassall, G Kaur, C Lewis… - Annals of …, 2019 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) affects approximately 2% of children in the United States
(US) yet its etiology is unclear and effective treatments are lacking. Therapeutic interventions …

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

DA Rossignol, RE Frye - Frontiers in physiology, 2014 - frontiersin.org
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders that are defined solely on the basis of behavioral observations. Therefore, ASD …