The role of cytokines in the pathogenesis of acute pancreatitis

J Norman - The American Journal of Surgery, 1998 - Elsevier
Background: The systemic manifestations of acute pancreatitis are responsible for the
majority of pancreatitis-associated morbidity and mortality and are now believed to be due to …

Molecular actions of ebselen—an antiinflammatory antioxidant

T Schewe - General Pharmacology: The Vascular System, 1995 - Elsevier
1. Ebselen (2-phenyl-1, 2-benzisoselenazol-3 (2H)-one) is a non-toxic seleno-organic drug
with antiinflammatory, antiatherosclerotic and cytoprotective properties. 2. 2. Ebselen and …

Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis

AS Gukovskaya, E Vaquero, V Zaninovic, FS Gorelick… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: Intrapancreatic activation of digestive enzymes is a key event in
the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the …

Oxidative stress in acute and chronic pancreatitis

MH Schoenberg, D Birk, HG Beger - The American journal of clinical …, 1995 - Elsevier
Oxygen radicals mediate an important step in the initiation of acute pancreatitis. These
reactive oxygen metabolites are generated at an early stage of the disease. The source of …

Role of oxidative stress in the pathogenesis of acute pancreatitis

JH Sweiry, GE Mann - Scandinavian Journal of Gastroenterology, 1996 - Taylor & Francis
During the last 10 years, the role of oxidative stress in pancreatitis and the benefits or
otherwise of antioxidants has been the subject of numerous research papers. There is …

Early trypsinogen activation in acute pancreatitis

MM Lerch, FS Gorelick - Medical Clinics of North America, 2000 - Elsevier
The exocrine pancreas synthesizes and secretes more protein per cell than any other
exocrine organ. Much of its protein secretion consists of digestive proenzymes, called …

Inhibition of nuclear factor-κB activation improves the survival of rats with taurocholate pancreatitis

A Satoh, T Shimosegawa, M Fujita, K Kimura… - Gut, 1999 - gut.bmj.com
Background Death in the early stages of severe acute pancreatitis is frequently the result of
multiple organ dysfunction, but its mechanism is not clear. Aims To investigate the state of …

Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis

A Dąbrowski, SJ Konturek, JW Konturek… - European journal of …, 1999 - Elsevier
In the last decade, the role of oxidative stress has been extensively evaluated in different
experimental models of acute pancreatitis. This review shows that there is strong evidence …

Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2‐mediated oxidative stress and NLRP3 inflammatory pathway

Z Dong, H Shang, YQ Chen, LL Pan… - Oxidative medicine …, 2016 - Wiley Online Library
Acute pancreatitis (AP) is characterized by early activation of intra‐acinar proteases followed
by acinar cell death and inflammation. Cellular oxidative stress is a key mechanism …

[HTML][HTML] Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats

M Eşrefoğlu, M Gül, B Ateş, K Batçıoğlu… - World journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To investigate the role of oxidative injury in pancreatitis-induced hepatic damage and
the effect of antioxidant agents such as melatonin, ascorbic acid and N-acetyl cysteine on …