Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways
and correcting misfolded proteins in cancer cells by interacting with oncogenic client …

Abstract The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent
molecular chaperone whose primary function is to ensure the proper folding of several …

Numerous drugs and endogenous ligands bind to cell surface receptors leading to
modulation of downstream signaling cascades and frequently to adaptation of the plasma …

Rationale: The heat shock protein (Hsp) system plays important roles in cancer stem cell
(CSC) and non-CSC populations. However, limited efficacy due to drug resistance and …

Abstract Heat shock protein 90 (HSP90), a highly and unique chaperone, presents as a
double-edged sword. It plays an essential role in many physiological and pathological …

Lysine acetylation is one of the major posttranslational modifications (PTM) in human cells
and thus needs to be tightly regulated by the writers of this process, the histone acetyl …

Rationale: Resistance to targeted therapies like trastuzumab remains a critical challenge for
HER2-positive breast cancer patients. Despite the progress of several N-terminal HSP90 …

Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …

Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus,
Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing …

Abstract Background Heat shock proteins (HSPs) are evolutionarily conserved proteins,
produced by cells in response to hostile environmental conditions, that are vital to organism …