Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …
Calcium-based biomaterials for diagnosis, treatment, and theranostics
Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates,
calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing …
calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing …
A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and …
In treatment of hypoxic tumors, oxygen‐dependent photodynamic therapy (PDT) is
considerably limited. Herein, a new bimetallic and biphasic Rh‐based core–shell …
considerably limited. Herein, a new bimetallic and biphasic Rh‐based core–shell …
Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy
Bacterial resistance to antibiotics has made it necessary to resort to using antibacterial drugs
that have considerable toxicities. Here, we show that conjugation of vancomycin-loaded …
that have considerable toxicities. Here, we show that conjugation of vancomycin-loaded …
An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury
Artificial enzymes have attracted wide interest in disease diagnosis and biotechnology due
to high stability, easy synthesis, and cost effectiveness. Unfortunately, their catalytic rate is …
to high stability, easy synthesis, and cost effectiveness. Unfortunately, their catalytic rate is …
Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy
In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …
potential biomedical applications. With its controllable geometry, tunable nanoporous …
Organelle-specific triggered release of immunostimulatory oligonucleotides from intrinsically coordinated DNA–metal–organic frameworks with soluble exoskeleton
DNA has proven of high utility to modulate the surface functionality of metal–organic
frameworks (MOFs) for various biomedical applications. Nevertheless, current methods for …
frameworks (MOFs) for various biomedical applications. Nevertheless, current methods for …
Carbogenic nanozyme with ultrahigh reactive nitrogen species selectivity for traumatic brain injury
Reactive oxygen and nitrogen species (RONS), especially reactive nitrogen species (RNS)
are intermediate products during incidence of nervous system diseases, showing …
are intermediate products during incidence of nervous system diseases, showing …
Strategies for targeted delivery of exosomes to the brain: advantages and challenges
Delivering therapeutics to the central nervous system (CNS) is difficult because of the blood–
brain barrier (BBB). Therapeutic delivery across the tight junctions of the BBB can be …
brain barrier (BBB). Therapeutic delivery across the tight junctions of the BBB can be …
Nanotechnology-based strategies for siRNA brain delivery for disease therapy
Small interfering RNA (siRNA)-based gene silencing technology has demonstrated
significant potential for treating brain-associated diseases. However, effective and safe …
significant potential for treating brain-associated diseases. However, effective and safe …