The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

INTRODUCTION Vision provides a critical survival advantage but requires a tight coupling
between neuronal energy demands and their vascular supply. The degeneration and …

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …