New Findings What is the topic of this review? We review recent work relating to exercise‐
induced alterations in mitochondrial structure and function. What advances does it highlight …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

Respirometry is the gold standard measurement of mitochondrial oxidative function, as it
reflects the activity of the electron transport chain complexes working together. However, the …

Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …

Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the
degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its …

Changes in skeletal muscle respiratory capacity parallel that of aerobic fitness. It is unknown
whether mitochondrial content, alone, can fully account for these differences in skeletal …

Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to
form citrate in the mitochondrial membrane, which participates in energy production in the …

Protein synthesis and autophagy are regulated by cellular ATP content. We tested the
hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species …

Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia,
yet aspects of this process remain controversial. Broadly, environmental hypoxia has been …

The mechanisms underlying muscle dysfunction with Chronic Obstructive Pulmonary
Disease (COPD) are poorly understood. Indirect evidence has recently suggested a role of …