Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …

Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Osteoarthritis, as a degenerative disease, is a common problem and results in high
socioeconomic costs and rates of disability. The most commonly affected joint is the knee …

Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …

Cues from the extracellular environment, including physical stimuli, are well known to affect
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …

The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the
early paradigm of cell replacement and differentiation as a therapeutic mechanism of action …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …

Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …