Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances

JM Lee, H Lee, SB Kang, WJ Park - Nutrients, 2016 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human
health and development, and numerous fatty acid desaturases play key roles in synthesizing …

Lipids and lipid metabolism in eukaryotic algae

IA Guschina, JL Harwood - Progress in lipid research, 2006 - Elsevier
Eukaryotic algae are a very diverse group of organisms which inhabit a huge range of
ecosystems from the Antarctic to deserts. They account for over half the primary productivity …

Docosapentaenoic acid (22: 5n-3): a review of its biological effects

G Kaur, D Cameron-Smith, M Garg, AJ Sinclair - Progress in lipid research, 2011 - Elsevier
This article summarizes the current knowledge available on metabolism and the biological
effects of n-3 docosapentaenoic acid (DPA). n-3 DPA has not been extensively studied …

Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of …

A Mühlroth, K Li, G Røkke, P Winge, Y Olsen… - Marine drugs, 2013 - mdpi.com
The importance of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health
has received more focus the last decades, and the global consumption of n-3 LC-PUFA has …

The versatility of algae and their lipid metabolism

JL Harwood, IA Guschina - Biochimie, 2009 - Elsevier
Eukaryotic algae are a very diverse group of organisms that are key components of
ecosystems ranging from deserts to the Antarctic. They account for over half of the primary …

Vertebrate fatty acyl desaturase with Δ4 activity

Y Li, O Monroig, L Zhang, S Wang… - Proceedings of the …, 2010 - National Acad Sciences
Biosynthesis of the highly biologically active long-chain polyunsaturated fatty acids,
arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids, in …

LC-PUFA from photosynthetic microalgae: occurrence, biosynthesis, and prospects in biotechnology

I Khozin-Goldberg, U Iskandarov, Z Cohen - Applied microbiology and …, 2011 - Springer
Microalgae offer potential for numerous commercial applications, among them the
production of long-chain polyunsaturated fatty acids (LC-PUFAs). These valuable fatty acids …

[HTML][HTML] The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human …

HG Park, WJ Park, KSD Kothapalli… - The FASEB Journal, 2015 - ncbi.nlm.nih.gov
Docosahexaenoic acid (DHA) is a Δ4-desaturated C22 fatty acid and the limiting highly
unsaturated fatty acid (HUFA) in neural tissue. The biosynthesis of Δ4-desaturated …

Molecular mechanisms for biosynthesis and assembly of nutritionally important very long chain polyunsaturated fatty acids in microorganisms

X Qiu, X Xie, D Meesapyodsuk - Progress in Lipid Research, 2020 - Elsevier
Very long chain polyunsaturated fatty acids (VLCPUFAs) such as docosahexaenoic acid
(DHA, 22: 6n-3), arachidonic acid (ARA, 20: 4n-6) and eicosapentaenoic acid (EPA, 20: 5 …

Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis

A Meyer, H Kirsch, F Domergue, A Abbadi… - Journal of lipid …, 2004 - ASBMB
In algae, the biosynthesis of docosahexaenoic acid (22: 6ω3; DHA) proceeds via the
elongation of eicosapentaenoic acid (20: 5ω3; EPA) to 22: 5ω3, which is required as a …