Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Preeclampsia (PE) is a multifactorial pregnancy disorder characterized by hypertension and
proteinuria, posing significant risks to both maternal and fetal health. Despite extensive …

Galectins, a family of glycan-binding proteins, are well-known for their role in shaping the
immune microenvironment. They can directly affect the activity and survival of different …

BACKGROUND The establishment of maternal–fetal crosstalk is vital to a successful
pregnancy. Glycosylation is a post-translational modification in which glycans …

Galectins comprise a family of soluble β-galactoside-binding proteins, which regulate a
variety of key biological processes including cell growth, differentiation, survival, and death …

Although the concepts related to fetal immune tolerance proposed by Sir Peter Medawar in
the 1950s have not withstood the test of time, they revolutionized our current understanding …

Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many
processes required for a successful pregnancy. Over the past decades, increasing evidence …

Galectin-14 is specifically expressed in placental trophoblasts, and its expression is reduced
in trophoblasts retrieved from the cervix of women destined to develop early pregnancy loss …

Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (eg
preeclampsia [PE]) with long-lasting consequences for the mother and offspring. The …

Protein N-linked glycosylation is a structurally diverse post-translational modification that
stores biological information in a larger order of magnitude than other post-translational …