Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …

We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal
dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until …

Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased
susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic …

Background Identification of lobar spontaneous intracerebral haemorrhage associated with
cerebral amyloid angiopathy (CAA) is important because it is associated with a higher risk of …

Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The
APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer's and cardiovascular …

In the two years of COVID-19 pandemic, the SARS-CoV-2 variants have caused waves of
infections one after another, and the pandemic is not ending. The key mutations on the S …

Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation.
Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of …

Alzheimer's Disease (AD) is a neurodegenerative disorder that can cause life-altering and
debilitating cognitive decline. AD's etiology is poorly understood, and no disease-modifying …

Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain
phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing …

Astrocytes play a formative role in memory consolidation during physiological conditions;
when dysregulated, astrocytes release glial fibrillary acidic protein (GFAP), which has been …