[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
[HTML][HTML] Sex hormone fluctuation and increased female risk for depression and anxiety disorders: from clinical evidence to molecular mechanisms
M Kundakovic, D Rocks - Frontiers in neuroendocrinology, 2022 - Elsevier
Women are at twice the risk for anxiety and depression disorders as men are, although the
underlying biological factors and mechanisms are largely unknown. In this review, we …
underlying biological factors and mechanisms are largely unknown. In this review, we …
Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts
BackgroundThe COVID-19 pandemic and mitigation measures are likely to have a marked
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …
Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities
Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …
Could polygenic risk scores be useful in psychiatry?: a review
Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …
Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …
used data from individuals of European descent. This limits the understanding of the …
Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts
Y Milaneschi, N Kappelmann, Z Ye, F Lamers… - Molecular …, 2021 - nature.com
We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …
symptoms, and whether these associations are potentially causal. Data was from 147,478 …
The genetic architecture of the human cerebral cortex
KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …
Variations in human cortical surface area and thickness are associated with neurological …
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
BackgroundSmoking prevalence is higher amongst individuals with schizophrenia and
depression compared with the general population. Mendelian randomisation (MR) can …
depression compared with the general population. Mendelian randomisation (MR) can …