In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that
mediates homotypic and heterotypic cell-cell adhesion. As an important member of the …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Maintenance of epithelial tissues needs the stroma. When the epithelium changes, the
stroma inevitably follows. In cancer, changes in the stroma drive invasion and metastasis …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Cell migration is a process which is essential during embryonic development, throughout
adult life and in some pathological conditions. Cadherins, and more specifically the neural …

The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a
lethal event of uncertain molecular etiology. Comparing gene expression in isogenic …

Microglia are the tissue-resident immune cells of the central nervous system, where they
constitute the first line of defense against any pathogens or injury. Microglia are highly motile …

purpose. To develop and characterize a telomerase-immortalized human corneal epithelial
cell line (hTCEpi) to serve as an in vitro model for studying the molecular mechanisms …