The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular
parasites of humans and animals with immense socio-economic and health impacts. We …

Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

Tumor-draining lymph nodes (TDLNs) are important for tumor antigen–specific T cell
generation and effective anticancer immune responses. However, TDLNs are often the …

Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …

The basic organisation of the endomembrane system is conserved in all eukaryotes and
comparative genome analyses provides compelling evidence that the endomembrane …

In the apicomplexans, endocytosed cargos (eg, hemoglobin) are trafficked to a specialized
organelle for digestion. This follows a unique endocytotic process at the …