RNA molecules, such as long noncoding RNAs (lncRNAs), have critical roles in regulating
gene expression, chromosome architecture, and the modification states of chromatin …

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …

R‐loops (RL s) are three‐stranded nucleic acid structures that contain a DNA: RNA hybrid
and a displaced DNA strand. Genomic regions with GC skew and a G‐rich transcript are …

Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleus by
the nuclear exosome. An exosome adaptor complex called NEXT (nuclear exosome …

Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount
role (s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double …

Endogenous and exogenous factors can severely affect the integrity of genetic information
by inducing DNA damage and impairing genome stability. The protection of genome …

To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a
rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 …

Our genetic information is organized into chromatin, which consists of histones and proteins
involved in regulating DNA compaction, accessibility and function. Chromatin is decorated …

Antibody–drug conjugates (ADC) have emerged as one of the pillars of clinical disease
management in oncology. The biggest hurdle to widespread development and application of …

Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans |
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