N Laspata, P Kaur, SY Mersaoui, D Muoio… - Nucleic acids …, 2023 - academic.oup.com
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
S Toubiana, S Selig - The FEBS journal, 2018 - Wiley Online Library
R‐loops (RL s) are three‐stranded nucleic acid structures that contain a DNA: RNA hybrid and a displaced DNA strand. Genomic regions with GC skew and a G‐rich transcript are …
K Ogami, P Richard, Y Chen, M Hoque… - Genes & …, 2017 - genesdev.cshlp.org
Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleus by the nuclear exosome. An exosome adaptor complex called NEXT (nuclear exosome …
M Thomas, C Dubacq, E Rabut, BS Lopez… - Cells, 2023 - mdpi.com
Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role (s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double …
B Mikolaskova, M Jurcik, I Cipakova, M Kretova… - Current genetics, 2018 - Springer
Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. The protection of genome …
Y Wang, X Liu, X Zuo, C Wang, Z Zhang, H Zhang… - Cell Genomics, 2024 - cell.com
To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 …
Our genetic information is organized into chromatin, which consists of histones and proteins involved in regulating DNA compaction, accessibility and function. Chromatin is decorated …
ER Boghaert, MC Cox, KS Vaidya - Cancer Research, 2022 - AACR
Antibody–drug conjugates (ADC) have emerged as one of the pillars of clinical disease management in oncology. The biggest hurdle to widespread development and application of …