Drug delivery across barriers to the middle and inner ear

Z Zhang, X Li, W Zhang… - Advanced functional …, 2021 - Wiley Online Library
The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat
these conditions. Here, recent advances in drug delivery systems that access the ear …

Re-visiting the tympanic membrane vicinity as core body temperature measurement site

WK Yeoh, JKW Lee, HY Lim, CW Gan, W Liang… - PloS one, 2017 - journals.plos.org
Core body temperature (CBT) is an important and commonly used indicator of human health
and endurance performance. A rise in baseline CBT can be attributed to an onset of flu …

Volume shrinkage of bone, brain and muscle tissue in sample preparation for micro-CT and light sheet fluorescence microscopy (LSFM)

J Buytaert, J Goyens, D De Greef… - Microscopy and …, 2014 - academic.oup.com
Two methods are especially suited for tomographic imaging with histological detail of
macroscopic samples that consist of multiple tissue types (bone, muscle, nerve or fat): Light …

A state-of-the-art analysis of pharmacological delivery and artificial intelligence techniques for inner ear disease treatment

W Li, N Zheng, Q Zhou, MS Alqahtani… - Environmental …, 2023 - Elsevier
Over the last several decades, both the academic and therapeutic fields have seen
significant progress in the delivery of drugs to the inner ear due to recent delivery methods …

Design, fabrication, and in vitro testing of novel three-dimensionally printed tympanic membrane grafts

ED Kozin, NL Black, JT Cheng, MJ Cotler, MJ McKenna… - Hearing research, 2016 - Elsevier
The tympanic membrane (TM) is an exquisite structure that captures and transmits sound
from the environment to the ossicular chain of the middle ear. The creation of TM grafts by …

Noninvasive depth‐resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media

GL Monroy, RL Shelton, RM Nolan… - The …, 2015 - Wiley Online Library
Objective/Hypothesis In this study, optical coherence tomography (OCT) is used to
noninvasively and quantitatively determine tympanic membrane (TM) thickness and the …

Biomimetic tympanic membrane replacement made by melt electrowriting

M von Witzleben, T Stoppe, T Ahlfeld… - Advanced …, 2021 - Wiley Online Library
The tympanic membrane (TM) transfers sound waves from the air into mechanical motion for
the ossicular chain. This requires a high sensitivity to small dynamic pressure changes and …

Treatment of otitis media by transtympanic delivery of antibiotics

R Yang, V Sabharwal, OS Okonkwo… - Science translational …, 2016 - science.org
Otitis media is the most common reason US children receive antibiotics. The requisite 7-to
10-day course of oral antibiotics can be challenging to deliver in children, entails potential …

Inaccuracies of deterministic finite-element models of human middle ear revealed by stochastic modelling

A Ebrahimian, H Mohammadi, JJ Rosowski… - Scientific reports, 2023 - nature.com
For over 40 years, finite-element models of the mechanics of the middle ear have been
mostly deterministic in nature. Deterministic models do not take into account the effects of …

Optical coherence tomography of the tympanic membrane and middle ear: a review

HEI Tan, PL Santa Maria… - … –Head and Neck …, 2018 - journals.sagepub.com
Objective To evaluate the recent developments in optical coherence tomography (OCT) for
tympanic membrane (TM) and middle ear (ME) imaging and to identify what further …