The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

Cells must continuously monitor and couple their metabolic requirements for ATP utilization
with their ability to take up O2 for mitochondrial respiration. When O2 uptake and delivery …

Reduced mitochondrial oxidative phosphorylation, via activation of adenylate kinase and the
resulting exponential rise in the cellular AMP/ATP ratio, appears to be a critical factor …

Abstract Sequestosome1/p62 (SQSTM1) is an oxidative stress-inducible protein regulated
by the redox-sensitive transcription factor Nrf2. It is not an antioxidant but known as a …

The malignancy of glioblastoma multiforme (GBM), the most common human brain tumor,
correlates with the presence of hypoxic areas, but the underlying mechanisms are unclear …

More than 800 different human membrane-spanning G-protein-coupled receptors (GPCRs)
serve as signal transducers at biological barriers. These receptors are activated by a wide …

With the advances of immunohistochemistry in combination with confocal microscopy,
airway sensory receptor end-organs can now be examined and evaluated objectively …

The pulsatile release of hormone is obligatory for the control of a range of important body
homeostatic functions. To generate these pulses, endocrine organs have developed finely …

Oxygen is a vital element for the survival of cells in multicellular aerobic organisms such as
mammals. Lack of O2 availability caused by environmental or pathological conditions leads …

Accumulating evidence suggests that podocyte hypoxia is an alternative mechanism for the
pathogenesis of renal diseases. Functional, large-conductance, calcium-activated …