Organic anion transporters in remote sensing and organ crosstalk
JC Granados, SK Nigam - Pharmacology & Therapeutics, 2024 - Elsevier
The organic anion transporters, OAT1 and OAT3, regulate the movement of drugs, toxins,
and endogenous metabolites. In 2006, we proposed that OATs and other SLC22 …
and endogenous metabolites. In 2006, we proposed that OATs and other SLC22 …
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy
H Hu, W Li, Y Hao, Z Peng, Z Zou, J Wei, Y Zhou… - Cell Reports …, 2024 - cell.com
Hyperuricemic nephropathy (HN) is a global metabolic disorder characterized by uric acid
(UA) metabolism dysfunction, resulting in hyperuricemia (HUA) and tubulointerstitial fibrosis …
(UA) metabolism dysfunction, resulting in hyperuricemia (HUA) and tubulointerstitial fibrosis …
Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases
L Xu, C Li, T Wan, X Sun, X Lin, D Yan, J Li… - Cell Communication and …, 2025 - Springer
Oxidative stress and neuroinflammation are recognized as key factors in the development of
neurodegenerative diseases, yet effective interventions and biomarkers to address oxidative …
neurodegenerative diseases, yet effective interventions and biomarkers to address oxidative …
[HTML][HTML] In Vivo Regulation of Small Molecule Natural Products, Antioxidants, and Nutrients by OAT1 and OAT3
The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) are drug
transporters that are expressed in the kidney, with well-established roles in the in vivo …
transporters that are expressed in the kidney, with well-established roles in the in vivo …
New Biomarkers for Renal Transporter‐Mediated Drug–Drug Interactions: Metabolomic Effects of Cimetidine, Probenecid, Verapamil, and Rifampin in Humans
The inhibition of renal transport proteins organic cation transporter 2 (OCT2), multidrug and
toxin extrusion proteins (MATE1, MATE2‐K), and organic anion transporters (OAT1, OAT3) …
toxin extrusion proteins (MATE1, MATE2‐K), and organic anion transporters (OAT1, OAT3) …
Dietary protein intake and the tubular handling of indoxyl sulfate
M Lauriola, R Farré, S Dejongh… - Nephrology Dialysis …, 2024 - academic.oup.com
Background Chronic kidney disease (CKD) patients are advised to limit their protein intake.
A high protein diet is known to induce glomerular hyperfiltration, as well as hypertrophy of …
A high protein diet is known to induce glomerular hyperfiltration, as well as hypertrophy of …
The Gut Microbiome in Hyperuricemia and Gout
R Terkeltaub, D Dodd - Arthritis & Rheumatology - Wiley Online Library
Humans develop hyperuricemia via decreased urate elimination and excess urate
production, consequently promoting monosodium urate crystal deposition and incident gout …
production, consequently promoting monosodium urate crystal deposition and incident gout …