Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

T cell immunoglobulin and mucin-containing molecule 3 (TIM-3), first identified as a
molecule expressed on interferon-γ producing T cells, is emerging as an important immune …

Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a new drug class approved for
treatment of diabetes, have been shown to possess a favorable metabolic profile and to …