The influence of the microbiome on respiratory health

TP Wypych, LC Wickramasinghe, BJ Marsland - Nature immunology, 2019 - nature.com
The revolution in microbiota research over the past decade has provided invaluable
knowledge about the function of the microbial species that inhabit the human body. It has …

Host–microbiota interactions in immune-mediated diseases

WE Ruff, TM Greiling, MA Kriegel - Nature Reviews Microbiology, 2020 - nature.com
Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

[HTML][HTML] Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

I Leonardi, IH Gao, WY Lin, M Allen, XV Li, WD Fiers… - Cell, 2022 - cell.com
Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …

Immune regulation by fungal strain diversity in inflammatory bowel disease

XV Li, I Leonardi, GG Putzel, A Semon, WD Fiers… - Nature, 2022 - nature.com
The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial
community colonizing the mammalian gastrointestinal tract and has an important role in …

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

T Kusakabe, WY Lin, JG Cheong, G Singh… - Nature …, 2023 - nature.com
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic
immune activation. Whether persistent pathobiont colonization during immune alterations …

Early life microbial exposures and allergy risks: opportunities for prevention

H Renz, C Skevaki - Nature Reviews Immunology, 2021 - nature.com
Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence,
particularly in westernized countries. Although a detailed mechanistic explanation for this …

The role of lung and gut microbiota in the pathology of asthma

W Barcik, RCT Boutin, M Sokolowska, BB Finlay - Immunity, 2020 - cell.com
Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

Pathogenesis of respiratory viral and fungal coinfections

F Salazar, E Bignell, GD Brown, PC Cook… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease

I Doron, M Mesko, XV Li, T Kusakabe, I Leonardi… - Nature …, 2021 - nature.com
Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by
shaping the resident microbiota community, restricting the growth of bacterial pathogens and …

Exploring the emerging role of the microbiome in cancer immunotherapy

J Fessler, V Matson, TF Gajewski - Journal for immunotherapy of cancer, 2019 - Springer
The activity of the commensal microbiota significantly impacts human health and has been
linked to the development of many diseases, including cancer. Gnotobiotic animal models …