The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …

Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …

The stress response is an essential mechanism for maintaining homeostasis, and its
disruption is implicated in several psychiatric disorders. On the cellular level, stress …

Hydroxynorketamines (HNKs) are formed in vivo after (R, S)-ketamine (ketamine)
administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl …

Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime
prevalence of 20% and, thus, is one of the most prevalent mental health disorders …

Stress-related psychiatric disorders such as depression are among the leading causes of
morbidity and mortality. Considering that many individuals fail to respond to currently …

The mechanism of action underlying ketamine's rapid antidepressant effects in patients with
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …

The experience of stress is often utilised in models of emerging mental illness and
neurobiological systems are implicated as the intermediary link between the experience of …

Major depressive disorder (MDD) is a debilitating disease characterized by depressed
mood, loss of interest or pleasure, suicidal ideation, and reduced motivation or …

Adaptive neuroplasticity is a pivotal mechanism for healthy brain development and
maintenance, as well as its restoration in disease-and age-associated decline. Management …