miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses
AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …
expression by sequential mechanisms such as mRNA breakdown or translational …
A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance
Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …
From resistance to resilience: Uncovering chemotherapeutic resistance mechanisms; insights from established models
Despite the tremendous advances in cancer treatment, resistance to chemotherapeutic
agents impedes higher success rates and accounts for major relapses in cancer therapy …
agents impedes higher success rates and accounts for major relapses in cancer therapy …
Recent insights into therapy resistance in osteosarcoma
ZD Prudowsky, JT Yustein - Cancers, 2020 - mdpi.com
Simple Summary Osteosarcoma is the most common cancer of the bone for children and
adolescents. Although chemotherapy regimens have been widely available and effective for …
adolescents. Although chemotherapy regimens have been widely available and effective for …
MicroRNA as a potential therapeutic molecule in cancer
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …
markers of neoplastic disease initiation and progression, but also markers of response to …
Demystifying the CXCR4 conundrum in cancer biology: Beyond the surface signaling paradigm
The oncogenic chemokine duo CXCR4-CXCL12/SDF-1 (CXC Receptor 4-CXC Ligand
12/Stromal-derived factor 1) has been the topic of intense scientific disquisitions since Muller …
12/Stromal-derived factor 1) has been the topic of intense scientific disquisitions since Muller …
Prostate cancer and the cell cycle: focusing on the role of microRNAs
Prostate cancer is the most frequent solid tumor in terms of incidence and ranks second only
to lung cancer in terms of cancer mortality among men. It has a considerably high mortality …
to lung cancer in terms of cancer mortality among men. It has a considerably high mortality …
Noncoding RNAs in osteosarcoma: implications for drug resistance
Z Lin, X Xie, S Lu, T Liu - Cancer Letters, 2021 - Elsevier
Osteosarcoma is the most frequent bone malignancy in children and adolescents. Despite
advances of surgery and chemotherapy in osteosarcoma over the past decades, overall …
advances of surgery and chemotherapy in osteosarcoma over the past decades, overall …
miR‐21 inhibition reverses doxorubicin‐resistance and inhibits PC3 human prostate cancer cells proliferation
W Zhao, L Ning, L Wang, T Ouyang, L Qi, R Yang… - Andrologia, 2021 - Wiley Online Library
Many approaches have been examined to reversing multidrug resistance (MDR), but sub‐
optimal target‐based strategies have limited their efficacy. Herein, we investigate microRNA …
optimal target‐based strategies have limited their efficacy. Herein, we investigate microRNA …
miRNA-based technologies in cancer therapy
The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …