Second-generation antiandrogens: from discovery to standard of care in castration resistant prostate cancer

MA Rice, SV Malhotra, T Stoyanova - Frontiers in oncology, 2019 - frontiersin.org
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States.
The prostate is a hormone-dependent gland in which androgen hormones testosterone and …

[HTML][HTML] The role of autophagy in resistance to targeted therapies

L Mele, V Del Vecchio, D Liccardo, C Prisco… - Cancer Treatment …, 2020 - Elsevier
Autophagy is a self-degradative cellular process, involved in stress response such as
starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule …

Novel insights into autophagy and prostate cancer: a comprehensive review

D Loizzo, SD Pandolfo, D Rogers, C Cerrato… - International Journal of …, 2022 - mdpi.com
Autophagy is a complex process involved in several cell activities, including tissue growth,
differentiation, metabolic modulation, and cancer development. In prostate cancer …

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation

M Ashrafizadeh, W Zhang, Y Tian, G Sethi… - Cancer and Metastasis …, 2024 - Springer
Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …

Potential roles and prognostic significance of exosomes in cancer drug resistance

M Mostafazadeh, N Samadi, H Kahroba, B Baradaran… - Cell & Bioscience, 2021 - Springer
Drug resistance is a major impediment in cancer therapy which strongly reduces the
efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical …

Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms

TL Ma, Y Zhou, C Wang, L Wang… - Oxidative medicine …, 2021 - Wiley Online Library
Ferroptosis is an iron‐dependent regulated necrosis characterized by the peroxidation
damage of lipid molecular containing unsaturated fatty acid long chain on the cell …

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling

C Lin, AM Blessing, TL Pulliam, Y Shi, SR Wilkenfeld… - Oncogene, 2021 - nature.com
Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer
progression in part through the modulation of autophagy. However, clinical trials testing …

Making the case for autophagy inhibition as a therapeutic strategy in combination with androgen-targeted therapies in prostate cancer

AM Elshazly, DA Gewirtz - Cancers, 2023 - mdpi.com
Simple Summary This paper is one in a series of articles that investigate the functional forms
of autophagy induced in tumor cells in response to various chemotherapeutic modalities …

Docosahexaenoic acid enhances the treatment efficacy for castration-resistant prostate cancer by inhibiting autophagy through Atg4B inhibition

Y Kudo, K Nakamura, H Tsuzuki, K Hirota… - Archives of Biochemistry …, 2024 - Elsevier
Autophagy induction in cancer is involved in cancer progression and the acquisition of
resistance to anticancer agents. Therefore, autophagy is considered a potential therapeutic …