Abstract This Consensus Statement covers recommendations for the diagnosis and
management of patients with pseudohypoparathyroidism (PHP) and related disorders …

Context: The term pseudohypoparathyroidism (PHP) indicates a group of heterogeneous
disorders whose common feature is represented by impaired signaling of various hormones …

Recent advances in understanding the epidemiology, genetics, diagnosis, clinical
presentations, skeletal involvement, and therapeutic approaches to hypoparathyroidism led …

The GNAS complex locus encodes the alpha-subunit of the stimulatory G protein (Gsα), a
ubiquitous signaling protein mediating the actions of many hormones, neurotransmitters …

Objective Disorders caused by impairments in the parathyroid hormone (PTH) signalling
pathway are historically classified under the term pseudohypoparathyroidism (PHP), which …

On binding of parathyroid hormone (PTH) to its receptor, the heptahelical PTH/PTHrP
receptor (PTH1R), leads to dissociation of Gsa (encoded by GNAS), the alphasubunit of the …

Bone development is a tightly regulated process. Several integrated signaling pathways
including HH, PTHrP, WNT, NOTCH, TGF-β, BMP, FGF and the transcription factors SOX9 …

Pseudohypoparathyroidism type 1a (PHP 1a) is characterized by hypocalcaemia and
hyperphosphatemia due to parathyroid hormone resistance, in association with the features …

Pseudohypoparathyroidism exemplifies an unusual form of hormone resistance as the
underlying molecular defect is a partial deficiency of the α subunit of the stimulatory G …

An update on the clinical and molecular characteristics of p... : Current Opinion in
Endocrinology, Diabetes and Obesity An update on the clinical and molecular …