Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in
the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal …

Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

Many cell types release extracellular vesicles (EVs), including exosomes, microvesicles
(MVs), and apoptotic bodies, which play a role in physiology and diseases. Presence and …

Multiple myeloma is a B-cell lineage cancer in which neoplastic plasma cells expand in the
bone marrow and pathophysiological interactions with components of microenvironment …

T-cell lymphomas are a heterogeneous group of cancers with different pathogenesis and
poor prognosis. Histone deacetylases (HDACs) are epigenetic modifiers that modulate …

The role of cancer-associated fibroblasts (CAFs) has not been previously studied in multiple
myeloma (MM). Here, cytofluorimetric analysis revealed higher proportions of bone marrow …

Multiple myeloma (MM) is a genetically heterogeneous disease that includes a subgroup of
10–15% of patients facing dismal survival despite the most intensive treatment. Despite …

Natural killer (NK) cells represent a subset of CD3-CD7+ CD56+/dim lymphocytes with
cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall …

Purpose: The aim of this study was to investigate the angiogenic role of the hepatocyte
growth factor (HGF)/cMET pathway and its inhibition in bone marrow endothelial cells (EC) …

In the modern process of drug discovery, clinical, functional and chemical proteomics can
converge and integrate synergies. Functional proteomics explores and elucidates the …