Simple Summary Neuroblastoma is a pediatric tumor originating from the precursors of
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …

Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-
risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result …

Platinum-based chemotherapies, including oxaliplatin, are a mainstay in the management of
solid tumors and induce cell death by forming intrastrand dinucleotide DNA adducts. Despite …

Simple Summary Neuroblastomas mostly show poor response to the Cisplatin therapy.
Amino acids serve as building blocks for proteins, which are acquired either through diet or …

Although short tandem repeat (STR) analysis is available as a reliable method for the
determination of the genetic origin of cell lines, the occurrence of misauthenticated cell lines …

Nucleotide excision repair (NER) is the process by which helix-distorting DNA lesions and
bulky adducts, such as those induced by UV (ultraviolet light), cisplatin, cigarette smoke, and …

Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …

Neuroblastoma is the most devastating extracranial solid malignancy in children. Despite an
intense treatment regimen, the prognosis for high-risk neuroblastoma patients remains poor …

Abstract GATA binding protein 3 (GATA3) is reported to critically involved in the
pathogenesis of neuroblastoma (NB). This study investigated the specific role and …

Platinum-based drugs are a mainstay of solid tumor treatment and act by inducing bulky
DNA adducts which should ultimately result in cell death. Unfortunately, these drugs have …