Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

Background Abnormal macrophage function caused by dysfunctional cystic fibrosis
transmembrane conductance regulator (CFTR) is a critical contributor to chronic airway …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

The endoplasmic reticulum (ER) is a dynamic structure, playing multiple roles including
calcium storage, protein synthesis and lipid metabolism. During cellular stress, variations in …

The expanding roles of macrophages in physiological and pathophysiological mechanisms
now include normal tissue homeostasis, tissue repair and regeneration, including neuronal …

Transformation of naive macrophages into classically (M1) or alternatively (M2) activated
macrophages regulates the inflammatory response. Here, we identified that distinct Ca 2+ …

The endoplasmic reticulum (ER) stress is an important event in the pathogenesis of different
human disorders, including atherosclerosis. ER stress leads to disturbance of cellular …

Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate
the physiology of cells, including those of the immune system. In contrast to effects that are …

Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-
excitatory cells where they mediate significant store-operated calcium entry (SOCE), an …