The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled
receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures …

Corticotropin-releasing factor (CRF) and the related urocortin peptides mediate behavioral,
cognitive, autonomic, neuroendocrine and immunologic responses to aversive stimuli by …

Environments experienced by organisms during early development shape the character and
timing of developmental processes, leading to different probabilities of survival in the …

The environment experienced by developing organisms can shape the timing and character
of developmental processes, generating different phenotypes from the same genotype, each …

The corticotropin-releasing factor (CRF) system in fish functions to maintain homeostasis
during stress in part by regulating cortisol production via the hypothalamus–pituitary …

During evolution, mammals have developed remarkably similar molecular mechanisms to
respond to external challenges and maintain survival. Critical regulators of these …

Peptides of the corticotropin-releasing factor (CRF) family are expressed throughout the
central nervous system (CNS) and in peripheral tissues where they play diverse roles in …

Corticotropin-releasing hormone (CRH) coordinates hormonal and behavioral responses to
stress. The mitogen-activated protein kinase extracellular signal-related kinase 1/2 (ERK1/2) …

Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system
response needed to adapt to stress. If adaptation fails, hypersecretion of CRF continues and …

A coordinated activation of multiple interlinked signaling pathways involving cAMP-
dependent protein kinase (PKA) and mitogen-activated extracellular signal-regulated …