Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications
Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
Osteoporosis: an update on screening, diagnosis, evaluation, and treatment
SA Sabri, JC Chavarria, C Ackert-Bicknell… - …, 2023 - journals.healio.com
Osteoporosis screening, diagnosis, and treatment have gained much attention in the health
care community over the past 2 decades. During this time, creation of multispecialty …
care community over the past 2 decades. During this time, creation of multispecialty …
[HTML][HTML] Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae
become fused through formation of osteophytes. The genetic and epidemiological etiology …
become fused through formation of osteophytes. The genetic and epidemiological etiology …
Genomic inbreeding trends, influential sire lines and selection in the global Thoroughbred horse population
The Thoroughbred horse is a highly valued domestic animal population under strong
selection for athletic phenotypes. Here we present a high resolution genomics-based …
selection for athletic phenotypes. Here we present a high resolution genomics-based …
Osteoporosis: a long-term and late-effect of breast cancer treatments
CL Shapiro - Cancers, 2020 - mdpi.com
Simple Summary Osteoporosis is a prevalent condition affecting 200 million individuals
world-wide. Estimates are about one in three women will experience a fragility fracture of …
world-wide. Estimates are about one in three women will experience a fragility fracture of …
The genetic epidemiology of joint shape and the development of osteoarthritis
JM Wilkinson, E Zeggini - Calcified tissue international, 2021 - Springer
Congruent, low-friction relative movement between the articulating elements of a synovial
joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint …
joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint …
Use of Mendelian randomization to examine causal inference in osteoporosis
Epidemiological studies have identified many risk factors for osteoporosis, however it is
unclear whether these observational associations reflect true causal effects, or the effects of …
unclear whether these observational associations reflect true causal effects, or the effects of …
[HTML][HTML] Heterozygosity and homozygosity regions affect reproductive success and the loss of reproduction: A case study with litter traits in pigs
Runs of heterozygosity (ROHet) and homozygosity (ROH) harbor useful information related
to traits of interest. There is a lack of investigating the effect of ROHet and ROH on …
to traits of interest. There is a lack of investigating the effect of ROHet and ROH on …
Evolutionary insights into primate skeletal gene regulation using a comparative cell culture model
The evolution of complex skeletal traits in primates was likely influenced by both genetic and
environmental factors. Because skeletal tissues are notoriously challenging to study using …
environmental factors. Because skeletal tissues are notoriously challenging to study using …
Functional validation of osteoporosis genetic findings using small fish models
The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …