Increasing evidence corroborates the fundamental role of neuroinflammation in the
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the …

There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

Sepsis, a medical emergency, is the overwhelming host response to infection leading to
organ failure. The pathophysiology of this heterogeneous disease includes an inflammatory …

Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …