COVID-19, mast cells, cytokine storm, psychological stress, and neuroinflammation

D Kempuraj, GP Selvakumar, ME Ahmed… - The …, 2020 - journals.sagepub.com
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a new pandemic infectious disease that originated in China …

Mechanisms of blood–brain barrier dysfunction in traumatic brain injury

A Cash, MH Theus - International journal of molecular sciences, 2020 - mdpi.com
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

[HTML][HTML] A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of …

C Wu, M Du, R Yu, Y Cheng, B Wu, J Fu, W Tan… - Free Radical Biology …, 2022 - Elsevier
Traumatic brain injury (TBI) can lead to disability or devastating consequences with few
established treatments. Although ferroptosis has been shown to be involved in TBI, the …

[HTML][HTML] Traumatic brain injury imaging in the second near-infrared window with a molecular fluorophore

X Zhang, H Wang, AL Antaris, L Li, S Diao… - … (Deerfield Beach, Fla …, 2016 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, therefore
important to understanding pathogenesis. Here, we designed a bright, renal-excreted and …

Response of the cerebral vasculature following traumatic brain injury

A Salehi, JH Zhang, A Obenaus - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1 …

X Chen, C Chen, S Fan, S Wu, F Yang, Z Fang… - Journal of …, 2018 - Springer
Background Microglial polarization and the subsequent neuroinflammatory response are
contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile …

Biofluid biomarkers of traumatic brain injury

DV Agoston, A Shutes-David, ER Peskind - Brain injury, 2017 - Taylor & Francis
Primary objective: The purpose of this paper is to review the clinical and research utility and
applications of blood, cerebrospinal fluid (CSF), and cerebral microdialysis biomarkers in …

In vitro modeling of the neurovascular unit: advances in the field

A Bhalerao, F Sivandzade, SR Archie… - Fluids and Barriers of …, 2020 - Springer
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …

Inhibition of caspase 3 and caspase 9 mediated apoptosis: a multimodal therapeutic target in traumatic brain injury

A Unnisa, NH Greig, MA Kamal - Current neuropharmacology, 2023 - benthamdirect.com
Traumatic brain injury (TBI) is one of the significant causes of death and morbidity, and it is
hence a focus of translational research. Apoptosis plays an essential part in the …

The overlooked aspect of excitotoxicity: Glutamate‐independent excitotoxicity in traumatic brain injuries

J Tehse, C Taghibiglou - European journal of neuroscience, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and
individuals under 45 year age. A wide variety of cellular and molecular mechanisms have …