Sex steroid actions in male bone

D Vanderschueren, MR Laurent, F Claessens… - Endocrine …, 2014 - academic.oup.com
Sex steroids are chief regulators of gender differences in the skeleton, and male gender is
one of the strongest protective factors against osteoporotic fractures. This advantage in bone …

Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse

T Bettis, BJ Kim, MW Hamrick - Osteoporosis International, 2018 - Springer
Bone fractures in older adults are often preceded by a loss of muscle mass and strength.
Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to …

Muscle-bone interactions: From experimental models to the clinic? A critical update

MR Laurent, V Dubois, F Claessens… - Molecular and cellular …, 2016 - Elsevier
Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

The effects of exercise and activity-based physical therapy on bone after spinal cord injury

TW Sutor, J Kura, AJ Mattingly, DM Otzel… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) produces paralysis and a unique form of neurogenic disuse
osteoporosis that dramatically increases fracture risk at the distal femur and proximal tibia …

Osteoporosis in individuals with spinal cord injury

WA Bauman, CP Cardozo - PM&R, 2015 - Elsevier
The pathophysiology, clinical considerations, and relevant experimental findings with regard
to osteoporosis in individuals with spinal cord injury (SCI) will be discussed. The bone loss …

A systematic review of animal models of disuse-induced bone loss

MB Brent, A Brüel, JS Thomsen - Calcified Tissue International, 2021 - Springer
Objective Several different animal models are used to study disuse-induced bone loss. This
systematic review aims to give a comprehensive overview of the animal models of disuse …

Low-dose testosterone and evoked resistance exercise after spinal cord injury on cardio-metabolic risk factors: an open-label randomized clinical trial

AS Gorgey, RE Khalil, R Gill, DR Gater… - Journal of …, 2019 - liebertpub.com
The purpose of the work is to investigate the effects of low-dose testosterone replacement
therapy (TRT) and evoked resistance training (RT) on body composition and metabolic …

Sixteen weeks of testosterone with or without evoked resistance training on protein expression, fiber hypertrophy and mitochondrial health after spinal cord injury

AS Gorgey, ZA Graham, Q Chen… - Journal of Applied …, 2020 - journals.physiology.org
We investigated the effects of testosterone replacement therapy (TRT) with and without
evoked resistance training (RT) on protein expression of key metabolic and hypertrophy …

The relationship between testosterone therapy and rotator cuff tears, repairs, and revision repairs

EJ Testa, JA Albright, D Hartnett… - JAAOS-Journal of the …, 2023 - journals.lww.com
Methods: The PearlDiver database was queried for patients who were prescribed
testosterone for at least 90 days between 2011 and 2018 to evaluate the incidence of RCTs …

Sexual dimorphism in skeletal muscle protein turnover

GI Smith, B Mittendorfer - Journal of applied physiology, 2016 - journals.physiology.org
Skeletal muscle is the major constituent of lean body mass and essential for the body's
locomotor function. Women have less muscle mass (and more body fat) than men and are …