Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

The stereotypical spread of pathological protein inclusions and clinicopathological
heterogeneity are well described in neurodegenerative diseases. Accumulating evidence …

The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy
pathology, is a phenomenon central to Parkinson's disease (PD) pathogenesis. The …

Apolipoprotein E (APOE) ε4 genotype is associated with increased risk of dementia in
Parkinson's disease (PD), but the mechanism is not clear, because patients often have a …

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been
widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural …

Multiple system atrophy (MSA) is a rare oligodendroglial α-synucleinopathy characterized by
neurodegeneration in striatonigral and olivopontocerebellar regions and autonomic brain …

The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic,
pathological feature specific to Multiple system atrophy (MSA). Since the characterization of …

The prodromal phase of Parkinson's disease is characterized by aggregation of the
misfolded pathogenic protein α-synuclein in select neural centres, co-occurring with non …

ABSTRACT Background Patients with Parkinson's disease (PD) show motor symptoms as
well as various non‐motor symptoms. Postmortem studies of PD have suggested that initial …