Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …

Over and above frequency: Gamma oscillations as units of neural circuit operations

A Fernandez-Ruiz, A Sirota, V Lopes-dos-Santos… - Neuron, 2023 - cell.com
Summary Gamma oscillations (∼ 30–150 Hz) are widespread correlates of neural circuit
functions. These network activity patterns have been described across multiple animal …

[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease

MI Gabitto, KJ Travaglini, VM Rachleff, ES Kaplan… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

[HTML][HTML] Ultrafast two-photon imaging of a high-gain voltage indicator in awake behaving mice

V Villette, M Chavarha, IK Dimov, J Bradley, L Pradhan… - Cell, 2019 - cell.com
Optical interrogation of voltage in deep brain locations with cellular resolution would be
immensely useful for understanding how neuronal circuits process information. Here, we …

Towards deep learning with segregated dendrites

J Guerguiev, TP Lillicrap, BA Richards - Elife, 2017 - elifesciences.org
Deep learning has led to significant advances in artificial intelligence, in part, by adopting
strategies motivated by neurophysiology. However, it is unclear whether deep learning …

Distinct inhibitory circuits orchestrate cortical beta and gamma band oscillations

G Chen, Y Zhang, X Li, X Zhao, Q Ye, Y Lin, HW Tao… - Neuron, 2017 - cell.com
Distinct subtypes of inhibitory interneuron are known to shape diverse rhythmic activities in
the cortex, but how they interact to orchestrate specific band activity remains largely …

Alterations in cortical interneurons and cognitive function in schizophrenia

SJ Dienel, DA Lewis - Neurobiology of disease, 2019 - Elsevier
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

Parvalbumin and somatostatin interneurons contribute to the generation of hippocampal gamma oscillations

P Antonoudiou, YL Tan, G Kontou… - Journal of …, 2020 - Soc Neuroscience
γ-frequency oscillations (30-120 Hz) in cortical networks influence neuronal encoding and
information transfer, and are disrupted in multiple brain disorders. While synaptic inhibition …

Interneuron types as attractors and controllers

G Fishell, A Kepecs - Annual review of neuroscience, 2020 - annualreviews.org
Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …

Inhibitory interneurons regulate temporal precision and correlations in cortical circuits

JA Cardin - Trends in neurosciences, 2018 - cell.com
GABAergic interneurons, which are highly diverse, have long been thought to contribute to
the timing of neural activity as well as to the generation and shaping of brain rhythms …