Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

An original evidence review examined screening and diagnosis of hereditary nonpolyposis
colorectal cancer (HNPCC) and the subsequent outcomes in a population of newly …

Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as
hereditary nonpolyposis colorectal cancer) has been well described, little is known about …

Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6,
and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of …

Diseases at the molecular level are complex and patient dependent, necessitating
development of strategies that enable precision treatment to optimize clinical outcomes …

Background Preventive programs for individuals who have high lifetime risks of colorectal
cancer may reduce disease morbidity and mortality. Thus, it is important to identify the …

It has been controversial that men carrying a DNA mismatch repair (MMR) gene mutation
(Lynch syndrome) are at heightened risk of prostate cancer given that an increased risk is …

Lynch syndrome is an inherited disease caused by a germline mutation in one of four DNA
mismatch repair (MMR) genes. The clinical manifestations can be somewhat variable …

Lynch syndrome, familial adenomatous polyposis, and Mut Y homolog (MYH)-associated
polyposis are three major known types of inherited colorectal cancer, which accounts for up …

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and 30% of all
cases of CRC are believed to have a familial component and up to one-third of these (10%) …