AdipoRon reduces TGFβ1‐mediated collagen deposition in vitro and alleviates knee stiffness in vivo

A Dudakovic, AK Limberg, CE Bothun… - Journal of Cellular …, 2024 - Wiley Online Library
Arthrofibrosis, which causes joint motion restrictions, is a common complication following
total knee arthroplasty (TKA). Key features associated with arthrofibrosis include …

Biochemical markers of postsurgical knee arthrofibrosis: A systematic review

PB Wyatt, J Satalich, J Cyrus, C O'Neill… - Journal of Orthopaedics, 2023 - Elsevier
Introduction Postsurgical knee arthrofibrosis is a common complication associated with pain
and limited range of motion. Although the mechanism is unclear, many biochemical and …

The safety of adiponectin receptor agonist AdipoRon in a rabbit model of arthrofibrosis

HI Salmons, C Gow, AK Limberg… - … Engineering Part C …, 2023 - liebertpub.com
AdipoRon is an adiponectin receptor 1, 2 (ADIPOR1 and ADIPOR2) agonist with numerous
reported physiological benefits in murine models of human disease, including a proposed …

Human outgrowth knee fibroblasts from patients undergoing total knee arthroplasty exhibit a unique gene expression profile and undergo myofibroblastogenesis upon …

B Bayram, R Thaler, JW Bettencourt… - Journal of cellular …, 2022 - Wiley Online Library
Arthrofibrosis is characterized by excessive extracellular matrix (ECM) deposition that results
in restricted joint motion after total knee arthroplasties (TKAs). Currently, treatment options …

The epigenetic regulator BRD4 is required for myofibroblast differentiation of knee fibroblasts

A Dudakovic, B Bayram, JW Bettencourt… - Journal of cellular …, 2023 - Wiley Online Library
Arthrofibrosis, which is characterized by excessive scar tissue and limited motion, can
complicate the daily functioning of patients after total knee arthroplasty (TKA). Molecular …

Efficacy of ADIPOR1 and ADIPOR2 peptide‐agonist AdipoRon in preventing contracture in a rabbit model of arthrofibrosis

HI Salmons, MF Carstens, AK Limberg… - Journal of …, 2024 - Wiley Online Library
AdipoRon is an adiponectin receptor 1, 2 (ADIPOR1 and ADIPOR2) agonist with potential
antifibrotic effects. Whether AdipoRon can mitigate joint stiffness in a rabbit model of …

Arthroscopic management of elbow stiffness

J Sanchez-Sotelo - Journal of Experimental Orthopaedics, 2021 - Springer
The elbow is particularly prone to stiffness. Loss of elbow motion is very limiting, and can be
the result of trauma, primary osteoarthritis, heterotopic ossification and other conditions …

[PDF][PDF] 全真一气汤通过ACTA2 调节COPD 大鼠肺动脉平滑肌细胞收缩功能

蔡志胜, 王春娥, 陈可强 - 亚太传统医药 - aptm.com.cn
目的: 探讨全真一气汤通过ACTA2 调节COPD 大鼠肺动脉平滑肌细胞收缩功能的机制. 方法:
清洁级SD 大鼠18 只, 采用烟熏的方法建立COPD 大鼠模型, 随机分成中药组与模型组 …