Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …

Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …

While alternative splicing is known to diversify the functional characteristics of some genes,
the extent to which protein isoforms globally contribute to functional complexity on a …

Research of a past decade and a half leaves no doubt that complete understanding of
protein functionality requires close consideration of the fact that many functional proteins do …

This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …

The abundant existence of proteins and regions that possess specific functions without
being uniquely folded into unique 3D structures has become accepted by a significant …

Traditionally, protein–protein interactions were thought to be mediated by large, structured
domains. However, it has become clear that the interactome comprises a wide range of …

Protein aggregation is linked with neurodegeneration and numerous other diseases by
mechanisms that are not well understood. Here, we have analyzed the gain-of-function …