Cell death signaling
DR Green, F Llambi - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …
homeostasis and eliminates potentially harmful cells. There are three major types of …
A review on caspases: key regulators of biological activities and apoptosis
G Sahoo, D Samal, P Khandayataray… - Molecular neurobiology, 2023 - Springer
Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …
crucial role in homeostasis and programmed cell death. Caspases have been broadly …
[HTML][HTML] Regulation of NLRP3 inflammasome by phosphorylation
N Song, T Li - Frontiers in immunology, 2018 - frontiersin.org
The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain
containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns …
containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns …
Cell death assays for drug discovery
Cell death has an important role in many human diseases, and strategies aimed at
modulating the associated pathways have been successfully applied to treat various …
modulating the associated pathways have been successfully applied to treat various …
New insights into apoptosis signaling by Apo2L/TRAIL
F Gonzalvez, A Ashkenazi - Oncogene, 2010 - nature.com
Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …
Heat shock proteins: cellular and molecular mechanisms in the central nervous system
Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in
normal neural physiological function as well as in cell stress responses. The functions of …
normal neural physiological function as well as in cell stress responses. The functions of …
Hyperthermia: an effective strategy to induce apoptosis in cancer cells
K Ahmed, Y Tabuchi, T Kondo - Apoptosis, 2015 - Springer
Heat has been used as a medicinal and healing modality throughout human history. The
combination of hyperthermia (HT) with radiation and anticancer agents has been used …
combination of hyperthermia (HT) with radiation and anticancer agents has been used …
Granzyme B-induced apoptosis in cancer cells and its regulation
I Rousalova, E Krepela - International journal of …, 2010 - spandidos-publications.com
The granzyme B-induced cell death has been traditionally viewed as a primary mechanism
that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate …
that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate …
The engine driving the ship: metabolic steering of cell proliferation and death
MR Buchakjian, S Kornbluth - Nature reviews Molecular cell biology, 2010 - nature.com
Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it
is not fully understood how metabolic pathways such as glycolysis and the pentose …
is not fully understood how metabolic pathways such as glycolysis and the pentose …
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors
E Varfolomeev, T Goncharov, H Maecker, K Zobel… - Science …, 2012 - science.org
Tumor necrosis factor (TNF) family members are essential for the development and proper
functioning of the immune system. TNF receptor (TNFR) signaling is mediated through the …
functioning of the immune system. TNF receptor (TNFR) signaling is mediated through the …