Consensus summary statement of the international multidisciplinary consensus conference on multimodality monitoring in neurocritical care: a statement for …

P Le Roux, DK Menon, G Citerio, P Vespa, MK Bader… - Neurocritical care, 2014 - Springer
Neurocritical care depends, in part, on careful patient monitoring but as yet there are little
data on what processes are the most important to monitor, how these should be monitored …

Mechanisms of action, physiological effects, and complications of hypothermia

KH Polderman - Critical care medicine, 2009 - journals.lww.com
Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods

KH Polderman, I Herold - Critical care medicine, 2009 - journals.lww.com
Background: Hypothermia is being used with increasing frequency to prevent or mitigate
various types of neurologic injury. In addition, symptomatic fever control is becoming an …

Induced hypothermia and fever control for prevention and treatment of neurological injuries

KH Polderman - The Lancet, 2008 - thelancet.com
Increasing evidence suggests that induction of mild hypothermia (32–35° C) in the first hours
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …

Regulation of the cerebral circulation: bedside assessment and clinical implications

J Donnelly, KP Budohoski, P Smielewski, M Czosnyka - Critical care, 2016 - Springer
Regulation of the cerebral circulation relies on the complex interplay between
cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act …

Outcome, timing and adverse events in therapeutic hypothermia after out‐of‐hospital cardiac arrest

N Nielsen, J Hovdenes, F Nilsson… - Acta …, 2009 - Wiley Online Library
Background: Therapeutic hypothermia (TH) after cardiac arrest protects from neurological
sequels and death and is recommended in guidelines. The Hypothermia Registry was …

Monitoring of cerebrovascular autoregulation: facts, myths, and missing links

M Czosnyka, K Brady, M Reinhard, P Smielewski… - Neurocritical care, 2009 - Springer
The methods for continuous assessment of cerebral autoregulation using correlation, phase
shift, or transmission (either in time-or frequency-domain) were introduced a decade ago …

Twenty-five years of intracranial pressure monitoring after severe traumatic brain injury: a retrospective, single-center analysis

J Donnelly, M Czosnyka, H Adams, D Cardim… - …, 2019 - journals.lww.com
BACKGROUND Intracranial pressure (ICP) is a clinically important variable after severe
traumatic brain injury (TBI) and has been monitored, along with clinical outcome, for over 25 …

Individualizing thresholds of cerebral perfusion pressure using estimated limits of autoregulation

J Donnelly, M Czosnyka, H Adams, C Robba… - Critical care …, 2017 - journals.lww.com
Objectives: In severe traumatic brain injury, cerebral perfusion pressure management based
on cerebrovascular pressure reactivity index has the potential to provide a personalized …

Cerebral perfusion in sepsis-associated delirium

D Pfister, M Siegemund, S Dell-Kuster, P Smielewski… - Critical care, 2008 - Springer
Introduction The pathophysiology of sepsis-associated delirium is not completely
understood and the data on cerebral perfusion in sepsis are conflicting. We tested the …