Histone deacetylases: unique players in shaping the epigenetic histone code
The epigenome is defined by DNA methylation patterns and the associated posttranslational
modifications of histones. This histone code determines the expression status of individual …
modifications of histones. This histone code determines the expression status of individual …
Clinical development of histone deacetylase inhibitors as anticancer agents
DC Drummond, CO Noble, DB Kirpotin… - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract Acetylation is a key posttranslational modification of many proteins responsible for
regulating critical intracellular pathways. Although histones are the most thoroughly studied …
regulating critical intracellular pathways. Although histones are the most thoroughly studied …
Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells
We completed a multicenter study of the effects of pomegranate cold-pressed (Oil) or
supercritical CO2-extracted (S) seed oil, fermented juice polyphenols (W), and pericarp …
supercritical CO2-extracted (S) seed oil, fermented juice polyphenols (W), and pericarp …
The human peroxisome proliferator-activated receptor δ gene is a primary target of 1α, 25-dihydroxyvitamin D3 and its nuclear receptor
Peroxisome proliferator-activated receptor (PPAR) δ is the most widely expressed member
of the PPAR family of nuclear receptor fatty acid sensors. Real-time PCR analysis of breast …
of the PPAR family of nuclear receptor fatty acid sensors. Real-time PCR analysis of breast …
Anti‐tumor mechanisms of valproate: a novel role for an old drug
RA Blaheta, J Cinatl Jr - Medicinal research reviews, 2002 - Wiley Online Library
Abstract Valproic acid (VPA, 2‐propylpentanoic acid) is an established drug in the long‐term
therapy of epilepsy. During the past years, it has become evident that VPA is also associated …
therapy of epilepsy. During the past years, it has become evident that VPA is also associated …
Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions
We investigated whether dissimilar biochemical fractions originating in anatomically discrete
sections of the pomegranate (Punica granatum) fruit might act synergistically against …
sections of the pomegranate (Punica granatum) fruit might act synergistically against …
Epigenetic changes in prostate cancer: implication for diagnosis and treatment
LC Li, PR Carroll, R Dahiya - Journal of the National Cancer …, 2005 - academic.oup.com
Prostate cancer is the most common noncutaneous malignancy and the second leading
cause of cancer death among men in the United States. DNA methylation and histone …
cause of cancer death among men in the United States. DNA methylation and histone …
Modulation of iron transport proteins in human colorectal carcinogenesis
MJ Brookes, S Hughes, FE Turner, G Reynolds… - Gut, 2006 - gut.bmj.com
Background and aims: Total body iron and high dietary iron intake are risk factors for
colorectal cancer. To date there is no comprehensive characterisation of iron transport …
colorectal cancer. To date there is no comprehensive characterisation of iron transport …
The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells
WG Zhu, GA Otterson - Current Medicinal Chemistry-Anti …, 2003 - ingentaconnect.com
The potential anticancer activities of histone deacetylase (HDAC) inhibitors and DNA
methyltransferase (DNMT) inhibitors have been extensively studied in recent years. HDAC …
methyltransferase (DNMT) inhibitors have been extensively studied in recent years. HDAC …