Stress and cancer: mechanisms, significance and future directions

A Eckerling, I Ricon-Becker, L Sorski… - Nature Reviews …, 2021 - nature.com
The notion that stress and cancer are interlinked has dominated lay discourse for decades.
More recent animal studies indicate that stress can substantially facilitate cancer …

Role of interleukin-6 in depressive disorder

EYC Ting, AC Yang, SJ Tsai - International journal of molecular sciences, 2020 - mdpi.com
Major depressive disorder (MDD), which is a leading psychiatric illness across the world,
severely affects quality of life and causes an increased incidence of suicide. Evidence from …

Cancer-related fatigue—mechanisms, risk factors, and treatments

JE Bower - Nature reviews Clinical oncology, 2014 - nature.com
Fatigue is one of the most common adverse effects of cancer that might persist for years after
treatment completion in otherwise healthy survivors. Cancer-related fatigue causes …

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

P Czarny, P Wigner, P Galecki, T Sliwinski - Progress in Neuro …, 2018 - Elsevier
A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

Cancer-related inflammation: common themes and therapeutic opportunities

FR Balkwill, A Mantovani - Seminars in cancer biology, 2012 - Elsevier
Inflammatory cells and mediators are an essential component of the tumor
microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of …

[HTML][HTML] Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition

AS Laino, D Woods, M Vassallo, X Qian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Inflammatory mediators, including acute phase reactants and cytokines, have
been reported to be associated with clinical efficacy in patients with melanoma and other …

Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?

JE Bower, PA Ganz, MR Irwin, L Kwan… - Journal of clinical …, 2011 - ascopubs.org
Purpose Fatigue, depression, and sleep disturbance are common adverse effects of cancer
treatment and frequently co-occur. However, the possibility that inflammatory processes may …

Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis

J Giese-Davis, K Collie, KMS Rancourt… - Journal of clinical …, 2011 - ascopubs.org
Purpose Numerous studies have examined the comorbidity of depression with cancer, and
some have indicated that depression may be associated with cancer progression or survival …

Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications

JE Bower, DM Lamkin - Brain, behavior, and immunity, 2013 - Elsevier
Fatigue is one of the most common and distressing side effects of cancer and its treatment,
and may persist for years after treatment completion in otherwise healthy survivors. Guided …

Interleukin-6 as a therapeutic target in human ovarian cancer

J Coward, H Kulbe, P Chakravarty, D Leader… - Clinical cancer …, 2011 - AACR
Purpose: We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in
ovarian cancer via abrogation of a tumor-promoting cytokine network. Experimental Design …