Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …

Increasing evidence indicates that chromatin modifications are important regulators of
mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin …

Lysine methylation of histones in vivo occurs in three states: mono-, di-and tri-methyl.
Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic …

Posttranslational modification of histones has emerged as a key regulatory signal in
eukaryotic gene expression. Recent genetic and biochemical studies link H3-lysine 9 (H3 …

Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation
machinery to a highly localized domain at the 5′ portion of active mRNA coding regions …

Posttranslational modifications of histone tails regulate chromatin structure and transcription.
Here we present global analyses of histone acetylation and histone H3 Lys 4 methylation …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

The trithorax genes encode an evolutionarily conserved family of proteins that function to
maintain specific patterns of gene expression throughout cellular development. Members of …

Methylation of histone proteins is one of their many modifications that affect chromatin
structure and regulate gene expression. Methylation of histone H3 on lysines 4 and 79 …

Recent studies of histone methylation have yielded fundamental new insights pertaining to
the role of this modification in gene activation as well as in gene silencing. While a number …