Clinical pancreatic islet transplantation can be considered one of the safest and least
invasive transplant procedures. Remarkable progress has occurred in both the technical …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and
efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective …

Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for
diabetes treatment,. However, this therapeutic strategy has not been systematically …

Transplantation of pancreatic progenitors or insulin-secreting cells derived from human
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …

Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Diabetes mellitus, as one of the most challenging chronic diseases, currently affects over
387 million people worldwide and this number is estimated to increase to around 500 million …

Background Islet transplantation is indicated for patients with type 1 diabetes with severe
hypoglycaemia or after kidney transplantation. We did a randomised trial to assess the …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Clinical islet transplantation has progressed considerably over the past 12 years, and> 750
patients with type 1 diabetes have received islet transplants internationally over this time …