Topical products, widely used to manage skin conditions, have evolved from simple potions
to sophisticated delivery systems. Their development has been facilitated by advances in …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Mathematical models of skin permeability play an important role in various fields including
prediction of transdermal drug delivery and assessment of dermal exposure to industrial …

The outermost epidermal layer of the skin, the stratum corneum, is not simply a barrier that
safeguards skin integrity from external insults and invaders, it is also a delicately integrated …

Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …

Protein–membrane interactions (PMIs) are ubiquitous in cellular signaling. Initial steps of
signal transduction cascades often rely on transient and dynamic interactions with the inner …

The skin barrier is fundamental to terrestrial life and its evolution; it upholds homeostasis
and protects against the environment. Skin barrier capacity is controlled by lipids that fill the …

Intracellular lipid droplets (LDs) are the main cellular site of metabolic energy storage. Their
structure is unique inside the cell, with a core of esterified fatty acids and sterols, mainly …

Lipid peroxidation by reactive oxygen species (ROS) during oxidative stress is non-
enzymatic damage that affects the integrity of biological membrane, and alters the fluidity …

Stratum Corneum (SC), the outermost layer of skin, is mainly responsible for skin's barrier
function. The complex lipid matrix of SC determines these barrier properties. In this study …