Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
Viral innate immune evasion and the pathogenesis of emerging RNA virus infections
T Nelemans, M Kikkert - Viruses, 2019 - mdpi.com
Positive-sense single-stranded RNA (+ ssRNA) viruses comprise many (re-) emerging
human pathogens that pose a public health problem. Our innate immune system and, in …
human pathogens that pose a public health problem. Our innate immune system and, in …
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
RE Randall, S Goodbourn - Journal of general virology, 2008 - microbiologyresearch.org
The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …
controlling most, if not all, virus infections in the absence of adaptive immunity. However …
Biology and pathogenesis of chikungunya virus
O Schwartz, ML Albert - Nature Reviews Microbiology, 2010 - nature.com
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a
recent, unexpectedly severe epidemic in countries of the Indian Ocean region. Although …
recent, unexpectedly severe epidemic in countries of the Indian Ocean region. Although …
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses
Y Li, S Banerjee, Y Wang… - Proceedings of the …, 2016 - National Acad Sciences
The 2′, 5′-oligoadenylate (2-5A) synthetase (OAS)–RNase L system is an IFN-induced
antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS. Although all three …
antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS. Although all three …
TRIM25 enhances the antiviral action of zinc-finger antiviral protein (ZAP)
The host factor and interferon (IFN)-stimulated gene (ISG) product, zinc-finger antiviral
protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple …
protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple …
The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation
N Wauquier, P Becquart, D Nkoghe… - Journal of Infectious …, 2011 - academic.oup.com
Background. Rapidly spreading to new regions, including the islands of the Indian Ocean,
Central Africa, and Europe, Chikungunya fever is becoming a major problem of public …
Central Africa, and Europe, Chikungunya fever is becoming a major problem of public …
Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes.
Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to …
Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to …
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II
ABSTRACT The Old World alphaviruses are emerging human pathogens with an ability to
cause widespread epidemics. The latest epidemic of Chikungunya virus, from 2005 to 2007 …
cause widespread epidemics. The latest epidemic of Chikungunya virus, from 2005 to 2007 …