Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C
fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to …

It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …

With the wide adoption of genomic sequencing in children having seizures, an increasing
number of SCN2A genetic variants have been revealed as genetic causes of epilepsy …

With sweeping advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …

Pain is a complex process that involves both detection in the peripheral nervous system and
perception in the CNS. Individual-to-individual differences in pain are well documented, but …

Systematic administration of anti-inflammatory cytokine interleukin 4 (IL-4) has been shown
to improve recovery after cerebral ischemic stroke. However, whether IL-4 affects neuronal …

Chronic pain is a global unmet medical need. Most existing treatments are only partially
effective or have side effects that limit their use. Rapid progress in elucidating the …

Despite an increasing number of available therapies, the treatment of neuropathic pain
remains a major issue. Systematic reviews and meta‐analyses indicate that only a minority …

Small fibre neuropathy is a common pain disorder, which in many cases fails to respond to
treatment with existing medications. Gain-of-function mutations of voltage-gated sodium …