Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017
N Gatimel, J Moreau, J Parinaud, RD Léandri - Andrology, 2017 - Wiley Online Library
For over 30 years, sperm morphology assessment has been one of the most common tests
in evaluation of fertility. This review examines the clinical relevance of sperm morphology …
in evaluation of fertility. This review examines the clinical relevance of sperm morphology …
Aberrant protamine content in sperm and consequential implications for infertility treatment
S Francis, S Yelumalai, C Jones, K Coward - Human fertility, 2014 - Taylor & Francis
Human sperm express two types of protamine: protamine 1 (P1) and the family of protamine
2 (P2) proteins, with P1 and P2 normally existing in a ratio of approximately 1: 1. Both the …
2 (P2) proteins, with P1 and P2 normally existing in a ratio of approximately 1: 1. Both the …
Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men
SS Hammoud, DA Nix, AO Hammoud… - Human …, 2011 - academic.oup.com
BACKGROUND The sperm chromatin of fertile men retains a small number of nucleosomes
that are enriched at developmental gene promoters and imprinted gene loci. This unique …
that are enriched at developmental gene promoters and imprinted gene loci. This unique …
Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent
BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …
Protamine/DNA ratios and DNA damage in native and density gradient centrifuged sperm from infertile patients
J Castillo, L Simon, S de Mateo, S Lewis… - Journal of …, 2011 - Wiley Online Library
Protamines are the major nuclear proteins condensing DNA in the sperm nucleus. One of
their proposed functions is the protection of the genetic message delivered by the sperm. To …
their proposed functions is the protection of the genetic message delivered by the sperm. To …
Sperm chromatin condensation: epigenetic mechanisms to compact the genome and spatiotemporal regulation from inside and outside the nucleus
Y Okada - Genes & Genetic Systems, 2022 - jstage.jst.go.jp
Sperm chromatin condensation is a critical step in mammalian spermatogenesis to protect
the paternal DNA from external damaging factors and to acquire fertility. During chromatin …
the paternal DNA from external damaging factors and to acquire fertility. During chromatin …
Differential expression of protamine 1 and 2 genes in mature spermatozoa of normal and motility impaired semen producing crossbred Frieswal (HF× Sahiwal) bulls
Mature spermatozoa contain thousands of mRNA transcripts. These untranslated mRNA
may perhaps serve as a “footprint” of spermatogenesis since many of them might directly or …
may perhaps serve as a “footprint” of spermatogenesis since many of them might directly or …
Protamines: lessons learned from mouse models
L Arévalo, GE Merges, S Schneider… - Reproduction, 2022 - rep.bioscientifica.com
In brief Protamines package and shield the paternal DNA in the sperm nucleus and have
been studied in many mouse models over decades. This review recapitulates and updates …
been studied in many mouse models over decades. This review recapitulates and updates …
Phenotypic varieties of sperm pathology: genetic abnormalities or environmental influences can result in different patterns of abnormal spermatozoa
HE Chemes - Animal Reproduction Science, 2018 - Elsevier
The present paper reviews in detail ultrastructural and molecular studies addressed to
characterize different phenotypes of sperm pathology in sterile men. In each case …
characterize different phenotypes of sperm pathology in sterile men. In each case …
Protamine alterations in human spermatozoa
Protamines are the major nuclear proteins in sperm cells, having a crucial role in the correct
packaging of the paternal DNA. The fact that protamine haploinsufficiency in mice resulted in …
packaging of the paternal DNA. The fact that protamine haploinsufficiency in mice resulted in …