Stabilizers and their interaction with formulation components in frozen and freeze-dried protein formulations
This review aims to provide an overview of the current knowledge on protein stabilization
during freezing and freeze-drying in relation to stress conditions commonly encountered …
during freezing and freeze-drying in relation to stress conditions commonly encountered …
Advances in the study of supercooled water
In this review, we report recent progress in the field of supercooled water. Due to its
uniqueness, water presents numerous anomalies with respect to most simple liquids …
uniqueness, water presents numerous anomalies with respect to most simple liquids …
The biology of tardigrade disordered proteins in extreme stress tolerance
C Hesgrove, TC Boothby - Cell Communication and Signaling, 2020 - Springer
Disordered proteins have long been known to help mediate tolerance to different abiotic
stresses including freezing, osmotic stress, high temperatures, and desiccation in a diverse …
stresses including freezing, osmotic stress, high temperatures, and desiccation in a diverse …
Structural comparison between sucrose and trehalose in aqueous solution
The two sugar molecules sucrose and trehalose are both considered as stabilizing
molecules for the purpose of preserving biological materials during, for example …
molecules for the purpose of preserving biological materials during, for example …
Recent developments in the Raman and infrared investigations of amorphous pharmaceuticals and protein formulations: A review
A Hédoux - Advanced drug delivery reviews, 2016 - Elsevier
The success rate for drug discovery and the development of innovative therapeutic
strategies are intimately related to the physical properties of the solid-state condensed …
strategies are intimately related to the physical properties of the solid-state condensed …
Understanding and controlling food protein structure and function in foods: perspectives from experiments and computer simulations
FL Barroso da Silva, P Carloni… - Annual review of …, 2020 - annualreviews.org
The structure and interactions of proteins play a critical role in determining the quality
attributes of many foods, beverages, and pharmaceutical products. Incorporating a …
attributes of many foods, beverages, and pharmaceutical products. Incorporating a …
Protein immobilization capabilities of sucrose and trehalose glasses: the effect of protein/sugar concentration unraveled by high-field EPR
Disaccharide glasses are increasingly used to immobilize proteins at room temperature for
structural/functional studies and long-term preservation. To unravel the molecular basis of …
structural/functional studies and long-term preservation. To unravel the molecular basis of …
High hydrostatic pressure treatment of Arthrospira (Spirulina) platensis extracts and the baroprotective effect of sugars on phycobiliproteins
Abstract The effect of High Hydrostatic Pressure (HHP)(600 MPa; 300 s) upon
phycobiliproteins from Spirulina platensis extract, in aqueous systems, has been …
phycobiliproteins from Spirulina platensis extract, in aqueous systems, has been …
Mode coupling behavior and fragile to strong transition of trehalose in a binary mixture with water upon supercooling
We perform molecular dynamics simulations of a binary mixture of water and trehalose with
the TIP4P/Ice water model. We analyze the slow dynamics of trehalose molecules in the …
the TIP4P/Ice water model. We analyze the slow dynamics of trehalose molecules in the …
Stabilization of proteins embedded in sugars and water as studied by dielectric spectroscopy
In many products proteins have become an important component, and the long-term
properties of these products are directly dependent on the stability of their proteins. To …
properties of these products are directly dependent on the stability of their proteins. To …