Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Our understanding of how global changes in cellular metabolism contribute to human kidney
disease remains incompletely understood. Here we show that nicotinamide adenine …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Kidney fibrosis is the final common pathway of virtually all chronic kidney diseases (CKDs)
and is therefore considered to be a promising therapeutic target for these conditions …

Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell
population under homeostatic conditions. Upon infection and in cancer, blood neutrophil …

Chronic kidney disease (CKD) is a public health problem driven by myofibroblast
accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized …

Mesenchymal stem cells (MSCs) exert beneficial therapeutic effects in acute kidney injury
(AKI), while the detailed repair mechanism remains unclear. Herein, we probed the …

Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …

Simple Summary AML is a type of leukemia with a very unfavorable prognosis. Some of the
new therapeutic targets that are being investigated by researchers worldwide are …