The transparency of the eye lens depends on maintaining the native tertiary structures and
solubility of the lens crystallin proteins over a lifetime. Cataract, the leading cause of …

The camera eye lens of vertebrates is a classic example of the re‐engineering of existing
protein components to fashion a new device. The bulk of the lens is formed from proteins …

The nucleocapsid (N) protein is one of the four structural proteins of the SARS-CoV-2 virus
and plays a crucial role in viral genome organization and, hence, replication and …

Cataracts cause vision loss through the large-scale aggregation of eye lens proteins as a
result of ageing or congenital mutations. The development of new treatments is hindered by …

Conformational diseases, a general term comprising more than 40 disorders are caused by
the accumulation of unfolded or misfolded proteins. Improper protein folding (misfolding) as …

Cataract is the leading cause of blindness in the world. It results from aggregation of eye
lens proteins into high-molecular-weight complexes, causing light scattering and lens …

Age‐related lens cataract is the major cause of blindness worldwide. The mechanisms
whereby crystallins, the predominant lens proteins, assemble into large aggregates that …

Numerous mutations and covalent modifications of the highly abundant, long‐lived
crystallins of the eye lens cause their aggregation leading to progressive opacification of the …

Cataracts, a major cause of global blindness, contribute significantly to the overall
prevalence of blindness. The opacification of the lens, resulting in cataract formation …

The ability of a polypeptide to fold into a unique, functional, and three-dimensional structure
depends on the intrinsic properties of the amino acid sequence, function of the molecular …