Diabetes: models, signals, and control
The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …
biomedical engineering component, with traditions of success beginning in the early 1960s …
The oral minimal model method
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
Mathematical modeling of the glucose–insulin system: A review
P Palumbo, S Ditlevsen, A Bertuzzi… - Mathematical …, 2013 - Elsevier
Mathematical modeling of the glucose–insulin feedback system is necessary to the
understanding of the homeostatic control, to analyze experimental data, to identify and …
understanding of the homeostatic control, to analyze experimental data, to identify and …
[HTML][HTML] A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
P Buchwald - Theoretical biology and medical modelling, 2011 - Springer
Background Because insulin is the main regulator of glucose homeostasis, quantitative
models describing the dynamics of glucose-induced insulin secretion are of obvious interest …
models describing the dynamics of glucose-induced insulin secretion are of obvious interest …
Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification by glucose: experiments and modeling
MG Pedersen, A Tagliavini… - American Journal of …, 2019 - journals.physiology.org
Glucose-stimulated insulin secretion from pancreatic β-cells is controlled by a triggering
pathway that culminates in calcium influx and regulated exocytosis of secretory granules …
pathway that culminates in calcium influx and regulated exocytosis of secretory granules …
[HTML][HTML] A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell
The pancreas plays a critical role in maintaining glucose homeostasis through the secretion
of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by …
of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by …
[HTML][HTML] Mathematical modeling clarifies the paracrine roles of insulin and glucagon on the glucose-stimulated hormonal secretion of pancreatic alpha-and beta-cells
A Brown, ES Tzanakakis - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction Blood sugar homeostasis relies largely on the action of pancreatic islet
hormones, particularly insulin and glucagon. In a prototypical fashion, glucagon is released …
hormones, particularly insulin and glucagon. In a prototypical fashion, glucagon is released …
A bio-inspired glucose controller based on pancreatic β-cell physiology
Introduction: Control algorithms for closed-loop insulin delivery in type 1 diabetes have been
mainly based on control engineering or artificial intelligence techniques. These, however …
mainly based on control engineering or artificial intelligence techniques. These, however …
Advancing our understanding of the glucose system via modeling: a perspective
The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur,
continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's …
continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's …
Cellular modeling: insight into oral minimal models of insulin secretion
MG Pedersen, GM Toffolo… - American Journal of …, 2010 - journals.physiology.org
The oral glucose tolerance test and meal tolerance test are common clinical tests of the
glucose-insulin system. Several mathematical models have been suggested as means to …
glucose-insulin system. Several mathematical models have been suggested as means to …